Endocrine Abstracts

Introduction: The corticotrophin-releasing factor (CRF) family of neuropeptides and their receptors affect innate immunity. A fully working peripheral CRF system is present in adipose tissue. In obesity, macrophages and adipocytes interact causing local and systemic inflammation. In addition, macrophages and adipocytes share common characteristics including production of inflammatory cytokines in response to lipopolysaccharides (LPS) via the toll-like receptor-4 (TLR4) which b...

Introduction: Obesity lowers adiponectin levels. Adiponectin has anti-inflammatory effects. It has been suggested that the lower levels of adiponectin in obesity results in chronic low grade inflammation (CLGI). Aim of this study was to examine if plasma adiponectin is a valid marker of CLGI in normal weight, overweight and obese individuals. In addition, we also assessed adiponectin as marker of body fat and insulin resistanceMethods: We measured adipon...

We have previously shown that Corticotropin – releasing factor (CRF) and Urocortins (UCNs) induce the production of catecholamines from normal human and rat adrenal chromaffin and PC12 pheochomocytoma cells via induction of tyrosine hydroxylase, the rate limiting enzyme of catecholamine biosynthesis. We have also shown that CRF induces calcium ion entrance into the cytoplasm from both extracellular sources (influx) and from intracellular stores (mobilization) in PC12 cell...

Endocrine Connections, (2022), 11, (6), e210639 (DOI: https://doi.org/10.1530/EC-21-0639): ...